ProD.N.A.® and Science of Aging

Meet Dr. Ershadi

Valeria Sadigh Ershadi, MD, ProD.N.A. Brand Dermatologist, has dedicated her seasoned career to understanding the complex relationship between skin and the inner workings of the human body. 

Dr. Ershadi practices Clinical Dermatology in Milan, Italy, and focuses specifically on advancing skin cancer research. As a philosophy, she emphasizes the importance of unearthing one’s natural beauty without the use of surgery or injections, rather, improving the skin through healthy lifestyle choices and quality skincare products. 

Educated at the University of Pavia, the most prestigious medical school in Italy, Dr. Ershadi practiced dermatology while she simultaneously rose to become one of the most appreciated specialists in the fields of cutaneous oncology and autoimmune diseases. Additionally, Dr. Ershadi has contributed to the drafting of several books on clinical cosmetics and dermatology, while also collaborating with prevalent publications on the topic of skincare. 

A Closer Look Into The Science Of Aging

A combination of two culprits causes skin to age: the natural aging process and exposure to sunlight


Natural aging, also called “Intrinsic Aging” or chronological aging,” effects our DNA and is guided by the nature of our genes. Its speed varies from person to person, and there’s nothing one can do reverse this process at its source.

Intrinsic aging begins in our mid-20s and continues throughout our lives, even though it’s effects may not become evident for decades. 

As time progresses, the body’s chemistry shifts and the structural basis of your skin (collagen and elastin) begin to break down. This phenomenon prevents the skin from regaining its shape at its previous speed, and wrinkles, visible expression lines, and saggy skin will slowly emerge on one’s complexion.


The second type of aging we experience is called extrinsic aging, which is caused by factors outside of the body. 

The responsible parties include UV rays (UVA and UVB), pollution, cigarette smoke and other environmental factors, and high-energy visible (HEV) light, or, “blue light.” 

HEV light is primarily from the sun, but is also emitted by your smartphone, tablet and computer screen. Extrinsic Aging leads the skin to develop new dark spots, wrinkles and a dull, greyish color.


UV rays cause inflammation, immune changes, physical changes, impaired wound healing and DNA damage that promotes cellular senescence and carcinogenesis.

Solar UV exposure is a major factor for age-related changes such as skin cancer development, hyperpigmentation, fine lines, and wrinkles.

UV radiation produces both direct and indirect DNA damage, and each can result in mutagenesis in skin cells. UV exposure may account for up to 80% of the visible signs of aging in the skin including dryness, wrinkles, loss of skin tone, hyperpigmentation and photoaging. These factors all correlate with an increased risk of skin cancer.

So What Can We Do To Prevent Skin Aging?

A combination of two culprits causes skin to age: the natural aging process and exposure to sunlight


Sun protection is absolutely essential. Because the sun plays such a major role in premature aging, you must use sunscreen everyday. 

You can protect your skin by seeking shade, covering up with clothing, and using sunscreen that is both broad-spectrum  (spf 30-50) and water resistant. You should reapply the sunscreen every 2 hours if you venture into the water.


For proper skin health, it is important to stop smoking and reduce the amount of alcohol you consume. 

These behaviors dehydrate the skin and cause it to appear dry, all while your fine lines and wrinkles become more visible due to the lack of fluid in your body.


Wash your skin with a gentle product that does not cause irritation to avoid accelerating skin aging. Wash your skin twice a day to remove makeup and other substances that act as skin pollutants. 

Finally, always use a moisturizer that enhances the function of the stratum corneum to prevent skin from drying.


Avoid repetitive facial expressions that make the muscle contract (such as frowning and furrowing your brow). Try anti-aging facial exercises to stimulate collagen and elastin for a tighter-looking skin. I recommend that you do your anti-aging facial exercises for 20 minutes to promote the circulation of blood to the different areas of the face to increasing the oxygen supply in the muscles and skin.


Fresh fruits and vegetables may help prevent damage that leads to premature skin aging, while carbohydrates accelerate the aging process.

ProD.N.A. with GenoMatrix ®

The ProD.N.A. line is built upon GenoMatrix®, a revolutionary formulation of powerful enzymes derived from marine microalgae and other natural, active ingredients.

This proprietary concentration works within the layers of skin to support natural DNA maintenance to counteract the effects of aging from the inside out.

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The Science of DNA Maintenance Enzymes

Marine microalgae - a single cell organism found in the Mediterranean Sea - developed advanced enzymes to protect itself from the power of the sun on an inhospitable primitive Earth. This unique repair mechanism allowed protection against physical damage caused by UV radiation. 

These powerful enzymes support and improve the maintenance of DNA by improving natural process that corrects the flawed original, so the copy is a healthy clear one during the replication process, while also increasing the mechanism’s efficiency.

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